Tamarind pulp water extract contains sterol, terpene, saponin, citric acid, tartaric acid, and malic acid. is a tropical evergreen tree native to the fertile area throughout Africa and Southern Asia.

This study showed that tamarind pulp extract was generally safe and well tolerated at the tested dose. The relative kidney weight of male rats in the 1000 mg/kg bw group was increased ( p < 0.05). The relative spleen weight of female rats of the 200 mg/kg bw group was reduced ( p < 0.05). Body weight of male rats in the satellite 1000 mg/kg bw group was significantly increased in week 30 compared to the satellite control group ( p < 0.05). After six months, there were no significant change in body weight, hematologic, and clinical biochemistry profiles of the tested group. Relative organ weights, hematology and clinical biochemistry profiles were determined. Satellite groups were sacrificed one month later. After six months, control groups and the treatment group were sacrificed. Treatment groups received tamarind pulp extract at doses of 75, 200, 1000, satellite 1000 mg/kg bw per day for six months.

The control group and satellite control group received carboxymethylcellulose sodium (CMC-Na) 0.5% 1 mL/100 g bw (body weight) per day. Wistar rats were divided into six groups, with 20 animals of each sex per group. Tamarind pulp was extracted by reflux method, followed by freeze-drying to obtain dry extract. In this research, long-term use of tamarind pulp water extract safety was evaluated. Tamarind water extract has been shown to demonstrate an anti-obesity effect.